Skin Bioassay Senior Scientist

Nottingham | On-site

We are seeking a Skin Bioassay Senior Scientist to join a growing CRO environment developing advanced in vitro skin models and bioassays for both pharmaceutical and cosmetic applications.

This role is part of a strategic expansion of in-house skin capabilities, supporting both ongoing projects and the development of new model systems. You will play a key role in generating high-quality datasets, developing human-relevant skin models, and delivering impactful assay results for clients.

Working within a collaborative, fast-paced laboratory environment, you will contribute to the development of next-generation skin models, including reconstructed and full-thickness systems, while supporting a broad range of client-driven and internal projects.

Responsibilities:

Skin Model Development

• Develop and optimise in vitro skin models, including:
• Reconstructed Human Epidermis (RHE) models
• Full-thickness or full-skin equivalent systems
• Contribute to the evolution of increasingly complex, physiologically relevant models

Assay Development & Delivery

• Design and execute cosmetic and skin-related bioassays, including:
• Cell proliferation and viability assays
• Cytokine release and inflammatory markers
• Barrier function and sensitivity assessments
• Analyse and interpret experimental data, ensuring generation of robust, client-ready datasets

Molecular & Analytical Techniques

• Apply a range of techniques including:
• ELISA and immunoassays
• qPCR and molecular biology workflows
• Plate-based assay readouts
• Use imaging and histology-based approaches to assess skin structure and function

Applied Skin Science & Testing

• Evaluate cosmetic formulations and active compounds
• Investigate:
• Ageing processes and protective effects
• UV response (using in-house UV systems)
• Key skin proteins such as keratin and structural markers

Project Delivery & Lab Operations

• Deliver experimental work in line with project timelines and client expectations
• Prepare SOPs, reports, and technical documentation
• Troubleshoot experiments and contribute to continuous improvement initiatives
• Support a collaborative CRO environment including potential client interaction

About You

You are a hands-on scientist with experience in skin biology and in vitro model systems, comfortable working in a fast-paced, applied research or CRO environment.

You'll bring:

• Experience working with in vitro skin models (essential)
• Experience developing RHE (Reconstructed Human Epidermis) models
• Strong laboratory experience across cell-based assays and bioassays
• Knowledge of ELISA, immunoassays, qPCR, and cell culture techniques
• A practical, delivery-focused mindset with strong attention to detail

Highly desirable:

• Exposure to full-skin equivalent or 3D skin models
• Experience in cosmetic testing, skin ageing, or UV response studies
• Background in CROs or applied commercial research

PhD candidates or those with 2-3 years of relevant industry experience are both encouraged to apply.

This is a great opportunity to join a growing organisation at a key stage, where you will not only deliver projects but also help shape the future direction of skin model development within the business.

Apply now by attaching your CV in Word, or contact Paige Keenan for further information about this new role:

Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.