• Job title: R&D Technologist
• Location: Cambridge
• Contract Length: 12 months
• Working Hours: 37.5 hours/week
• Pay Rate: £15.83

About the Role

Opportunity to work in the cutting edge of R&D in the biopharmaceutical industry at a globally leading CDMO.

Key Responsibilities

• Contribute to the delivery of new mammalian expression hosts and vector systems for the expression of complex therapeutic proteins.
• Engineer mammalian cell lines (e.g. Stable cell line generation, targeted integration and gene editing - e.g. CRISPR-based systems).
• Generate mammalian expression vectors using state of the art assembly techniques.
• Phenotypic characterisation of edited cell lines with relevant assays (e.g. NGS, ddPCR, qPCR and flow cytometry) and cell culture techniques (e.g., shake flask/ bioreactor).
• Collate, analyse, evaluate and sign-off data to produce good quality information and traceable records under the direction of the project lead.
• Presentation of results in written and oral reports.
• Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein expression (in particular with R&D Process Development & Protein Analytics)
• Actively keep abreast of relevant academic literature (e.g., in the field of cell engineering and expression technologies).
• Contribute ideas and opinions to scientific discussions to aid the development of new technologies.
• Working both individually and as a team player - working with a high degree of flexibility.
• Execute studies in support of technology or process development projects.
• Supports development of study plans.
• Maintains accurate and timely records to appropriate quality standards for self and team, prepares high quality data summaries.

Key requirements:

• BSc/MSc Degree in Life Sciences / Science/ Molecular Biology
• Practical experience within in an industrial/academic setting is desirable.
• Good technical background in molecular biology (Electrophoresis, PCR, vector construction) and cell culture (preferably mammalian cells) with the aim of developing or manipulating mammalian expression systems.
• Clear demonstration of strong technical skills, scientific execution and data analysis.
• A proactive attitude to working and solving challenging problems.
• Good working knowledge of statistics and expertise in design of experiments.
• Experience of cell line engineering, ideally with CRISPR-based systems would be an advantage and highly desirable.
• Good understanding of synthetic biology technologies would be desirable.

Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.