PhD Genetic Engineer required, based in Cheshire. Requiring a PhD in Molecular Biology, Synthetic Biology, Bioengineering, Biotechnology, Genetics or similar, + experience with molecular biology tools, genetic manipulation of microbes and/or DNA sequencing
PhD Genetic Engineer
Salary: Circa £35,000 per annum
SRG is working with an innovative company who specialise in the creation of speciality chemicals for a range of markets. They have recently established a brand-new biotechnology research hub and are now looking for a PhD Genetic Engineer to lead work in developing new strains of microbes which will function as biocatalysts. You will use a variety of molecular biology and bioinformatic tools to engineer new metabolic pathways, with the goal of producing microbial strains with enhanced fermentation productivity and desired product yield. This would be a fantastic opportunity for a PhD-qualified Scientist to lead research in synthetic biology and genetic engineering with real commercial and industrially relevant outcomes.
Benefits: A research-led role in a highly-respected, multi-national company, with mentoring from a subject matter expert. Brand-new, purpose-built, state-of-the-art laboratory facilities and equipment. 37.5 hours, Mon-Fri, flexible working hours. Excellent company pension and bonus potential, private healthcare and 25 days holiday plus 8 statutory bank holidays.
Role / Description
- Developing targeted evolution methods to increase key enzyme performance in biosynthesis to enhance production of desired fermentation products
- Carrying out genetic manipulation of microbial candidates and biosynthetic pathway design and engineering
- Developing a genetic tool-kit for host microbial strains which allows for gene insertions and deletion/knockout and stable plasmids, if needed
- Evaluation of synthetic biocatalysts in micro- and shake flask fermentations
- Scaling up candidate strain fermentations, in collaboration with Microbiologists
- Preserving engineered biocatalysts using lyophilization and cryogenic methods
- Using modern molecular biology tools, including homologous recombination, CRISPR, conjugation, electroporation, vector-mediated transformation, gene splicing, DNA sequencing, PCR
- PhD in Microbial Genetics, Biotechnology, Bioengineering, Synthetic Biology, Molecular Biology or similar
- Proven experience (academic, post-doc or industrial) in the use of modern molecular biology and/or genetic engineering tools and methods (named above)
- Practical knowledge of directed evolution methods to improve metabolic function of enzymes or pathway flux
- Experience using bioinformatic programs associated with genetic engineering and pathway flux optimisation (e.g. Omics mining or similar)
- Good analytical chemistry skills for quantification and characterisation of metabolites
If you would like to apply for this position, please use the link provided. Alternatively please email a copy of your CV to email@example.com For more information regarding this position or any others, please call Jack on 0161 888 2557. If you have a scientific background and this position is not relevant / suitable for you, please feel free to get in touch or visit www.srgtalent.com to view our other vacancies.
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Keywords: transgenic, genetic engineering, genetic manipulation, biotechnology, microbial, genetics, bioengineering, bioprocess, enzyme, fermentation, biofermentation, biosynthesis, biocatalyst, synthetic biology, molecular biology, geneticist, bioengineer, CRISPR
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