SRG are currently looking to recruit a Research Associate in Mathematical Modelling to join a global agrochemical company based in the Berkshire area.
The associate will work on an exciting project to develop new mathematical models for developmental neurotoxicity evaluation.
Thyroid hormone activity is critical for normal brain development and therefore the impact of environmental chemicals that have the potential to interfere with thyroid signalling is a major concern with direct implications for neurodevelopmental health. Our client is offering an exciting 36-month position as Research Associate in their R&D department to develop mechanistic (differential equation) models to address these safety concerns.
This project will involve a wider multi-disciplinary collaboration, alongside an academic team from the University of Dusseldorf who will be responsible for generating data to support the development of the mathematical models. This will be a close collaboration with regular interactions to ensure close alignment of the modelling and experimental components.
The main areas of focus for the role will be: 1) developing spatial-temporal (partial differential equation) models that describe the development and metabolic status of 3D in vitro neurospheres; 2) developing maternal-foetal physiologically based kinetic (PBK) models to predict foetal exposure; and 3) integrating the neurosphere and maternal-foetal PBK models to build a new mathematical model for developmental neurotoxicity evaluation.
- Co-ordinate and contribute to the building of mathematical models for developmental neurotoxicity evaluation.
- Perform a scientific literature review of thyroid hormone regulation and the relevant mathematical approaches.
- Manage and interpret outputs from models including specification, conduct, problem solving, reporting and interpretation for deployment to end users.
- Develop PDE models for 3D in vitro neurospheres.
- Apply numerical and analytical methods to solve differential equations.
- Work collaboratively within a multidisciplinary team and with external partners.
- Develop a maternal-foetal physiologically based kinetic (PBK) model.
- Develop an integrated mechanistic model of maternal-foetal thyroid regulation.
- Communicate model development, utility, and limitations to a wide and varied community of end users, both internally and externally.
- Prepare peer-reviewed scientific publications and presentations for relevant conferences.
- A good honours degree in an analytical subject (e.g., mathematics, physics, computer science).
- Experience in the application of mathematical modelling for solving multidisciplinary problems in biology.
- An ideal candidate would have a PhD, or postdoctoral experience, in computational/mathematical biology (this includes PhD students who are near completion but have yet to submit). However, talented candidates without a PhD are also encouraged to apply.
- Good data handling skills.
- Good quantitative and computer-based numerical skills.
- Knowledge of programming and scripting in MATLAB.
- High motivation to publish in peer-reviewed journals and present at scientific conferences.
- Proactivity, creativity, problem solving and commitment to a goal.
- Flexible to manage running change and well organized to meet deadlines.
- Communication of complex modelling approaches to audiences with varied experience
- Excellent written and verbal communication skills.
Our Client will offer:
- Good onsite facilities
- Competitive salary
- Collaborative working environment with scientific specialists
- Flexible working conditions
Location: Bracknell, Berkshire
Contract duration: 3 years
If you have any questions or wish to discuss further, please contact Natalia Santoro at firstname.lastname@example.org
your application has been submitted