Role : Senior Scientist (Phenotypic Screening)
Duration : 12 months
Location : Cambridge - Darwin (On site)
Rates : Circa £25 per hour PAYE / £30 UMB
Do you have experience working with immunology cell cultures?
SRG are working with a leading pharmaceutical company and we are looking for a senior scientist to join the lab-based team of scientists that are developing CRISPR screening capabilities in Treg cells.
the ideal candidate will have extensive exposure to working with immunology cell cultures - T regs experience is highly sought after, if not then T cells is essential.
As a Phenotypic Screening Scientist, in the Functional Genomics (FGX) team in Cambridge, UK, you'll play a pivotal role in enabling target discovery to make a positive impact on changing patients' lives.
The Functional Genomics (FGX) team, within Discovery Sciences, is responsible for the identification of novel target hypothesis through the perturbation of disease relevant systems and driving AstraZeneca's clinical pipeline. To achieve this we have been developing robust screening cascades in primary cell types to deploy CRISPR reagents in phenotypic screens to identify novel targets of interest.
There is an exciting opportunity for you to join our team as a lab-based scientist to develop and deliver CRISPR screening capabilities in Treg cells. Applying your knowledge and expertise in immune cell biology and CRISPR screening you will be part of a multi-faceted project team and a valued member of our department.
Main Duties and Responsibilities
- Lab-based scientist, delivering expertise in immunology cellular screening, working in partnership with colleagues across AZ to build screening capabilities and deliver target ID screens.
- Generate quantitative data to identify and prioritise biological pathways for target validation.
- Maintain awareness of current developments in the literature and contribute to continuous improvement of techniques and processes.
- Represent the department and achieve scientific visibility through project contributions and presentations at internal meetings, as well as external collaborations, conference presentations and peer-reviewed publications.
- Ph.D in Biology, Molecular or Cell biology, Immunology or related discipline with 2+ years lab experience preferred
- MSc in a related discipline with 5+ years lab experience preferred
- Highly proficient in mammalian cell biology techniques including the isolation and culture of primary immune cells.
- Knowledge and experience in the development and execution of immune cell assays, ideally in miniaturised plate based formats and using high content/FACs based endpoints
- Candidates must have previous experience of working with blood; isolating and culture of cells
- Experience with cell screening + imaging (CRISPR)
- Experience of arrayed or pooled CRISPR screening highly desirable
- Experience working with automation
- Experience of NGS readouts
If this role is of interest to you, (or you know anyone who might be suitable), please email your CV to Tom O'Neill at email@example.com and a time that is convenient for me to call you.
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