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Job Title: Synthetic Biologist/Biochemist - Enzyme EngineerLocation: Stevenage, UKContract: 12 Month FTC
SRG are working with a global pharmaceutical company to help them find a highly motivated individual with experience in protein directed evolution, especially with application to the discovery and engineering of enzymes for use in industrially relevant processes. The successful candidate would participate in an interdisciplinary team tasked with identifying optimal opportunities for implementing enzyme process across the pharma portfolio.
The successful applicant can expect excellent onward training in analytical development as well as the opportunity to collaborate with experts working in other disciplines; particularly formulation, manufacturing, regulatory and synthetic chemistry.
Responsibilities:* Generating libraries of enzyme variants for high throughput expression* Developing appropriate assays to screen variants in high throughput* Running screens to identify improved variants* Designing experiments, collecting data and analysing data to make good decisions* Support scale up activities for generation and use of enzymes* Analyse and visualise large-scale datasets using programs such as MS Excel, TIBCO Spotfire and bespoke software tools.* Liaise with scientists & external collaborators at all levels* Generate conclusion reports, present data in team meetings & participate in writing of abstracts & publications* Conduct scientific work programs and make contributions both independently and as a member of a team with other R&D staff* Work through problems logically and apply innovative solutions* Adopt new technologies and apply them to project work
Requirements:* Ph.D. in Enzyme/Protein engineering, Biocatalysis, Biochemistry, Synthetic Biology or related field, or 3-5 years relevant experience in engineering biocatalysts. A strong knowledge of biochemical reactions and the application of analytical techniques to monitor these reactions is essential* Experience with molecular cloning, site-directed mutagenesis, and large-scale variant library construction.* Experience in high throughput recombinant enzyme assays* Demonstrated ability to work in multi-disciplinary teams, displaying excellent interpersonal, organizational, and communication skills
Preferable Qualifications:* Experience with parallel experimentation, high throughput assay development, Design of Experiments, etc.* Familiarity with lab automation equipment and its use in high throughput experimentation* Ability to analyse and visualise large multidimensional datasets* Experience with next generation sequencing and the analysis of next generation sequencing results* Demonstrated excellence in the end to end execution of directed evolution projects including enzyme identification, library design, generation, and screening
To apply click the link or send your CV to firstname.lastname@example.org
Key words: Enzyme / Biochemistry / Synthetic Biology / Biocatalysis / Biologist / Enzyme Engineer / Analytical / R&D