Research Associate - AAV gene delivery

Research Associate - AAV gene delivery
  • Competitive
    ANNUM
  • Permanent
  • Cambridge, Cambridgeshire, England, UK cb24 4qe Cambridge Cambridgeshire UK cb24 4qe
Job Ref: J2160060
Sector: Science
Sub-sector: Biotech/Life Sciences
Date Added: 21 April 2021
Research Associate - Gene Synthesis AAV development Cambridge Permanent

Research Associate: AAV Gene Delivery (adeno-associated virus)

Cambridge

Permanent

£ Competitive depending on skills, experience and background

An entrepreneurial gene synthesis organisation are seeking a Research Associate to support with their ambitious growth plans, within the R&D team. Your role will be pivotal in supporting the scaling of a proprietary DNA manufacturing process, and development of non-viral nanoparticles and AAV vectors for DNA delivery.

Core role requirements:

  • Development and optimisation of AAV vectors for gene therapy

  • Take a lead on the production and purification systems to develop research-grade AAV

  • Suggest ways for improvement of the AAV production through use of synthetic DNA templates

  • Performance of analytical techniques on vector preparations such as q-PCR, ELISA, protein gels

  • Maintaining an accurate LIMS, ensuring the validity and efficacy of data and records, maintenance of laboratory equipment according to health and safety guidance and SOPs

  • Attend and participate in company meetings, training and professional development sessions as required

  • You may be required to travel to other sites as necessary (with notice)

Person specification:

  • Extensive background in working with AAV production and purification using HEK293 cells

  • PhD or Masters in a relevant discipline plus industry experience in an area with good synergy to gene synthesis and AAV production

  • Proven hands-on skills with classic molecular skills (western blot, PCR, flow cytometry), cell culture (transfection, infection, banking, revival etc) and experience working with cell-based assays (ELISA)

  • You will also need some good working knowledge of cloning DNA constructs in bacterial systems

If this role profile sounds like what you want to do next, and your CV proves you have the necessary skills and experience to do it, then please apply now through the link or contact Bec Johnston for more information: bec.johnston@srgtalent.com.

SRGTalent
21/05/2021 15:01:43
GBP Annum
Contact Consultant:
Bec Johnston2

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