Scientist - Upstream Process Development
This is a role where you will be able to apply your experience in a cutting-edge environment working for a growing company in an innovative environment. This is an exciting opportunity for a talented scientist to contribute to the development of novel, state-of-the-art mammalian cell culture upstream processes for exosome-based biotherapeutic products.
The role:* Design and execute experiments to develop and optimise cell culture batch, fed batch and perfusion processes for exosome products.* Mammalian cell culture using single use bioreactors such as shake flasks, high throughput systems such as amr15/ambr250 and 2L stirred tank systems and WAVE bioreactors.* Apply statistical approaches for process optimisation (DoE, QbD) at small scale (15/250ml ambr high throughput) and translation of small-scale results to process scale-up.* Scale up of upstream processes (10-200L) to confirm process performance.* Experience of routine analytical techniques such as SDS-PAGE, Western Blotting and biochemical assays is desirable. * Support technology transfer activities for commercial manufacturing.* Work collaboratively with Research, Cell Line Development, Downstream Process Development, Research Manufacturing and Quality to develop and establish new techniques and recommend alternative approaches and potential solutions to upstream process development issues.Skills and Experience:* PhD in relevant area with industrial laboratory experience in biologics and/or cell/viral product process development or BSc/MSc with more direct industrial laboratory experience.* Proven industry experience in mammalian suspension cell culture batch and fed-batch process development, optimisation and scale up most probably gained in with protein and/or viral products.* Experience of basal medium and feed development, control, and optimisation.* Experience in the development of perfusion processes would be advantageous.* Experience in adherent cell culture, expansion and scale out would be advantageous but not essential.* Understanding and experience of development and establishment of in-process analytical methods as applied to mammalian cell culture processes.
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